Microalgas como sistemas de expresión para la producción de proteínas recombinantes
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Contenido principal del artículo
Resumen
En el campo de la biotecnología, las proteínas recombinantes han revolucionado muchas
industrias, incluyendo la farmacéutica, la agricultura y la bioenergía. Al producir proteínas de
alto valor en huéspedes heterólogos, las fábricas celulares pueden ofrecer una solución más
eficiente, rentable, escalable y amigable con el ambiente, en comparación con la producción
de proteínas y métodos de extracción tradicionales, que pueden exigir muchos recursos y
mano de obra. Las microalgas han emergido como huéspedes atractivos debido a su estatus
como organismos Generalmente Reconocidos como Seguros (GRAS), su metabolismo versátil,
diversidad genética entre especies, facilidad de cultivo y escalabilidad y su rentabilidad general.
Para la ingeniería genética, su capacidad para síntesis compleja de proteínas y modificaciones
post-traduccionales y su relativa facilidad de transformación hacen a las microalgas una solución
ventajosa en muchos aspectos. Las microalgas pueden ser transformadas para permitir la
expresión eficiente de proteína, más comúnmente en el núcleo y el cloroplasto, cada uno con
sus ventajas y limitaciones. La presente revisión de literatura compila algunas de las técnicas,
características y últimos avances relacionados con la producción de proteínas recombinantes
en microalgas, explorando diferentes técnicas de transformación genética y sus limitaciones.
La producción recombinante de proteínas es solo uno de los muchos procesos que se pueden
convertir más sostenibles y eficientes al usar microalgas como una plataforma.
Detalles del artículo
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